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On one hand, there are GHRH analogs (sermorelin, CJC-1295, tesamorelin) that activate the cAMP/PKA pathway
Owing to their structural diversity, broad range of sources, and biological activity, these compounds hold great prospect for the development of modern drugs targeting hair greying
At the same time, compared to HCs, the levels of a wide range of metabolites such as glutamine, asparagine, N-Formimino-glutamate, putrescine, serotonin, kynurenine, 2-Aminomuconate, Cys-Gly, 5-Aminolevulinate, and pyridoxine were reduced in the plasma of R group ( Figure 5C , Supplementary Figure 4A )
Protein thiol homeostasis: Glutathione maintains proteins in their reduced (functional) state through S-glutathionylation, a reversible post-translational modification that regulates protein activity under oxidative stress [2]
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