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These features are not typical of benign muscle soreness and require evaluation to rule out conditions like deep vein thrombosis, cellulitis, or compartment syndrome

People with sensitive digestive systems should start with low doses or avoid berberine-containing products entirely

There is no strong evidence of kidney damage in healthy individuals using normal doses

Obtaining coverage may be difficult otherwise, but this is an evolving field as more clinical trial data emerge

Therefore, while aware that the pharmacological modulation of the NRF2/ARE pathway could undeniably offer new therapeutic opportunities for diseases related to OS, we should at the same time consider that most of the currently known activators of NRF2 are not particularly specific, leading to an increased risk of off target toxic effects