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As more research emerges, understanding of GLP-1 receptor agonists continues to grow and Professor Badve likens them to the ACE inhibitors which similarly underwent a broadening of their list of indications over time

Valente et al [11] reported that continuous administration of a PDE5 inhibitor to rats prevented the formation of fibrotic plaque and decreased plaque size

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The major cardiovascular safety trials The SUSTAIN-6 trial enrolled 3,297 patients with type 2 diabetes and high cardiovascular risk, following them for two years on semaglutide 0.5 mg or 1.0 mg weekly versus placebo