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5:2 : Eating normally for five days and significantly reducing calorie intake for two days

Key points: Melanotan-II is being increasingly promoted on platforms like TikTok and YouTube The drug has been promoted as a product that can give its users a tan, but it can have serious health risks The TGA is targeting social media influencers and warning of big fines for people who are promoting dangerous products Last month the Therapeutic Goods Administration (TGA) issued a warning about Melanotan-II, a substance being widely spruiked on social media platforms such as TikTok and Instagram

doi: 10.1016/j.peptides.2022.170749 41 CoskunTSloopKWLoghinCAlsina-FernandezJUrvaSBokvistKBet al

The typical pattern involves rapid initial improvement followed by more gradual ongoing enhancement

The standard pharmacokinetic rule is 4-5 half-lives for steady state