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Description

These physiologically low-toxicity ligands, upon AhR activation, tend to induce transcriptional programs that maintain mucosal homeostasis and immune tolerance, including stabilization of Treg phenotypes, enhancement of the IL-22-mediated barrier protection axis, and suppression of excessive Th17-driven inflammation, thereby functionally biasing AhR signaling toward immune protection in this context (Zelante et al., 2013

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