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The crossing of these cellular barriers is essential for the development of the IMD, and although it has been intensively studied, it remains not fully understood

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Sleep disruption, anxiety, low libido, brain fog, mood changes, muscle loss, stubborn weight gain, and changes in energy or motivation are often connected to hormonal and metabolic shifts happening beneath the surface

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3.2 Lactic acidosis During metformin treatment, plasma lactate concentration increases with enhanced glucose uptake in the intestine, resulting in side effects in some patients with one or more risk factors for lactic acidosis (Bailey et al., 1992