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Treatments like chiropractic care or stretch therapy work from the outside in, addressing structural alignment, mobility, and muscle tension
In cancer, however, DDR exerts a paradoxical influence: while repair deficiencies promote mutagenesis and tumorigenesis, restoration or hyperactivation of DDR pathways in established tumors fosters resistance by enabling efficient repair of therapy-induced DNA damage
L.Garca-FontanaB.CamejoD.JimnezA.SevillaS.et al
STAT February 2026
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