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Another study showed that Puerarin could block cisplatin-induced activation of TRPV1 and IP3R1, prevent intracellular calcium overload, and inhibit p65 to reduce excessive ROS production, thereby ameliorating cisplatin-induced ototoxicity and blocking apoptosis (Lin et al., 2024)

Additionally, optimization methods for tankyrase inhibitors can guide structural improvements of new anti-cancer drugs (Kamal et al., 2014)

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Independence from Growth Hormone Pathways A defining characteristic of AOD9604 is its selective activity profile that excludes classical growth hormone effects

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