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Moreover, MG149, an acetyltransferase inhibitor targeting the MYST domain of KAT8, reduces Pan Kla levels in CRC cells, highlighting the tumor-suppressive potential of KAT8 inhibitors in high-lactate TME
Conflating the mechanism with the outcome
Additionally, HIF-1 promotes angiogenesis via VEGF expression and contributes to immunosuppression by increasing nitric oxide synthases (iNOS, NOS2) activity in myeloid cells and recruiting regulatory T-cells through VEGFneuropilin-1 signaling
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