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There is also a risk of accidental overdose when you deviate from the prescribed dosing schedule

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Patients should not interpret the absence of a specific heartburn label in trial data as confirmation that the symptom cannot occur individual responses to any medicine can vary considerably, and this investigational profile may be updated as further evidence emerges

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Additionally, a rating of each study based upon the number of subjects studied, time interval of testing, dosing, technical parameters that were quantified, etc