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Many prescribers recommend morning dosing with food to reduce nausea and to anchor it to a daily routine, improving adherence. If you tend to drink mainly in the evening, morning dosing still works because opioid receptor blocking happens across a 24hour period
I have witnessed people with uncontrolled Hashimotos and overt hypothyroidism who can work an 80 hour week, run a household, become elite body builders, and/or run marathons, while others can barely drag themselves out of bed in the morning and have to go on disability due to debilitating symptoms, even while taking thyroid meds
Inability to Keep Fluids Down: If severe vomiting or diarrhoea prevents you from staying hydrated, you are at risk of complications like acute kidney injury
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