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The dense ECM characteristic of osteosarcoma presents a physical barrier that restricts T cell infiltration and limits the penetration of therapeutic agents ( 3.4 Activating innate immune pathways through nanocarrier design The cGAS-STING pathway has emerged as a critical node for activating innate antitumor immunity, and its stimulation has shown promise in converting immunologically cold tumors into hot ones (56)

10.3390/cells9041048 93

Both compounds have been researched for growth hormone and IGF-1 levels in research models but they do it through different pathways resulting to different physiological responses in laboratory settings

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