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Effects of ritonavir and amprenavir on insulin sensitivity in healthy volunteers
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We proposed that the insulinotropic effect of this GLP-1R agonist (GLP-1RA) would synergize with the insulin-sensitizing effect of tesaglitazar to optimize glucose handling, while the body weight lowering effect of the GLP-1RA would buffer against any potential obesogenic activity of PPAR agonism
The activation of G 12/13 also induces serum-response factor-response element (SRF-RE)-mediated transcription, whereas the activation of Gq stimulates nuclear factor of activated T-cell response element (NFAT-RE)-mediated transcription 10,11,15
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