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Additionally, GLP-1 slows gastric emptying, meaning food stays in your stomach longer, enhancing feelings of fullness and allowing you to comfortably reduce portion sizes and frequency of meals

This pathway is initiated when TGF- ligands (TGF-1, TGF-2, and TGF-3) bind to TGF- receptor types I and II, activating SMAD proteins that modulate gene expression (Feng and Derynck 1997