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A maximum treatment duration of 2 years was assumed, with efficacy estimates based on an intention-to-treat analysis using the treatment-policy estimand, thereby capturing population-level effects irrespective of adherence or treatment modifications (41)

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65 While the traditional ketogenic diet (KD) has long been used for obesity management, it has also been associated with adverse effects on bone health, including compromised bone mass and structural integrity

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long-term safety data still accumulating