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11SURPASS-CVOT: seguridad y eficacia cardiovascular en DM2 con ASCVD establecida SURPASS-CVOT (Nicholls et al., NEJM, diciembre 2025) es el primer ensayo aleatorizado, doble ciego y guiado por eventos que evala los resultados cardiovasculares con tirzepatida en pacientes con DM2 y ASCVD establecida
These drugs change brain chemistry to reduce hunger and increase fullness
So, these therapies are adjuncts, not replacements for lifestyle improvement
MOTS-c (mitochondrial open-reading-frame of the 12S rRNA-c) is a peptide encoded by the mitochondria that enhances metabolic flexibility
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