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Chronic or heavy alcohol consumption increases CYP2E1 activity, which in turn elevates NAPQI formation from acetaminophen metabolism
All statistical analyses were performed using the GraphPad Prism 5.0 software (GraphPad Software Inc., San Diego, CA, USA) and SPSS 15.0 software (SPSS, Inc., Chicago, IL, USA)
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Probiotics play a crucial role in modulating prostaglandin E2 (PGE2), an anti-inflammatory prostanoid that inhibits the secretion of pro-inflammatory cytokines, such as IL-1 and TNF-, by macrophages (174)
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