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We do not assume the goal is the lowest possible number on the scale
For instance, if you have low potassium because you take diuretics, your doctor may take you off them or switch you to a different kind
Under these conditions, systemic metabolic adaptation increasingly depends on the availability of substrates required to sustain redox buffering, anabolic maintenance, and enzymatic throughput
Nat Med (2015) 21(1):815
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