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The GIP gene product has a 21 amino acid signal peptide (UniProt P09681) that targets the protein to rough endoplasmic reticulum (rER) and is cleaved by signal peptidases

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A large prospective cohort study that tracked over 1,700 patients demonstrated that patients who underwent a Roux-en-Y gastric bypass lost an excess 21% of their body mass normalized to their non-surgical matched controls at the 10 year point (corresponding to 35 kg (~77 lbs) greater weight loss)

Meanwhile, CAR-Ts, CAR-T regulatory T cells, chimeric autoantibody receptor (CAAR) T cells and other cell based treatments are being evaluated for various conditions, including gastrointestinal autoimmune diseases, including ulcerative colitis and Crohns disease, and in preclinical stages for chronic viral infections, such as HIV

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