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Differential toxicity appears linked to structural variations, influencing ROS modulation, apoptosis induction, and receptor interactions: - and -viniferins inhibit epithelial-mesenchymal transition (EMT) and ROS-mediated mechanisms in cancer cells (Chiou 2022)

In SURMOUNT-5, gastrointestinal adverse events were common in both groups, which is expected for this drug class

This is not a class change but a medication change within the same therapeutic category

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A study published in the New England Journal of Medicine, showed an average of 12.5% weight loss and over half lost 20% of their body weight