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A double-blind, placebo-controlled trial (2018) found significant improvements in verbal communication and core ASD symptoms in FRAA-positive children taking folinic acid (2 mg/kg/day, max 50 mg/day)
Concurrently, GLP-1 stimulates the translocation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) into the nucleus via the PKA/ERK signaling pathway, where Nrf2 induces transcription of genes for SOD, GPx, catalase, thioredoxin, and other antioxidant enzymes, further enhancing the cellular antioxidant defense system
Berberine can have its own GI side effects (diarrhea, nausea) that compound with GLP-1 side effects
These two stories are incredibly common
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