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Semaglutide: Promotes weight loss by reducing appetite and caloric intake via GLP-1 receptor activation Trevogrumab: Blocks myostatin, a protein that limits muscle growth, thereby promoting muscle mass increase Garetosmab: Inhibits activin A, AB, and AC, which are also negative regulators of muscle mass, further supporting muscle growth and fat reduction Clinical Trial Findings Phase 2 COURAGE Trial Design: Randomized, double-blind, with multiple arms including semaglutide alone, semaglutide plus trevogrumab (high/low dose), and semaglutide plus trevogrumab and garetosmab
Janocha AJ, Comhair S, Basnyat B, Neupane M, Gebremedhin A, Khan A, et al
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