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These genetic changes increase keratin and the thickness of the outer layer of skin
Thus, in mice, significant antihyperglycaemic effects of DPP-4 inhibition are still apparent in animals lacking the GLP-1 receptor (43), while in clinical studies, GLP-1 receptor antagonism (using exendin 9-39) eliminates only approximately half of the glucose-lowering effect in patients with T2DM treated with DPP-4 inhibitors (44, 45)
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doi: 10.1056/NEJMcibr2409089 Donnelly D
Lilly also has two publications in the oral delivery bucket - the earliest hint that an oral retatrutide or a retatrutide successor may be in preclinical development
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