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In colorectal cancer patients, co-treatment with Manuka honey (UMF 15+) and 5-fluorouracil (5-FU) increased intratumoral drug concentration by 62%, attributed to inhibition of efflux transporters such as P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) (135)
Dose-response studies have evaluated ranges from 0.8 to 7.5 mL/kg
In plants, SOD isozymes are present in the cytosol and mitochondria
Ancak her takviyede olduu gibi, glutatyonun da bilinli kullanm nemlidir
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