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Introduction Type 2 diabetes (T2D) is a complex disease that is characterized by elevated circulating glucose levels, which can lead to a significant reduction in the quality of life and severe complications such as kidney failure, amputations, and premature cardiovascular mortality 1,2
Indeed, Rhythms mid-stage study found one serious complication, rectal bleeding, that led to discontinuation
Researchers originally built it into a treatment for type 2 diabetes, not weight loss
Effect of canagliflozin and metformin on cortical neurotransmitters in a diabetic rat model
For me it would be interesting to see if GLP-1s can reduce inflammation and liver damage in other types of liver disease, including fatty liver from a combination of metabolic risk and alcohol consumption (Im guessing a decent fraction of Americans and Britons with fatty liver fall have both of these risk factors)
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