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Additional pharmacology data is available via the National Institutes of Health and FDA drug approvals database

GLP-1 heart benefits may be distinct from obesity effects The cardiovascular benefits derived from GLP-1 drugs may be more directly tied to dosage than to degree of weight loss, according to a study that suggests the effects of the medicine on the heart may be separate from the impact on obesity

In animal studies, semaglutide was associated with thyroid tumors

2.2 Primary culture of myocytes and thermal stress trial 2.2.1 Primary culture of myocytes Juvenile fish, each weighing approximately 5 g, were dissected under sterile conditions to obtain muscle tissue, which was then cut into pieces and transferred to a 24-well cell culture plate

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