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Indirect comparisons using network meta-analysis suggest tirzepatide 15 mg produces approximately 5, 6 percentage points greater weight loss than semaglutide 2.4 mg, but trial populations differ in ways that complicate direct comparison
In a head-to-head comparison, tirzepatide users lost an average of about 20% of body weight over 72 weeks, versus roughly 15% with semaglutide (source: NEJM)
These include Alzheimers Disease where neuroprotective effects are under investigation followed by stroke under similar notion (125) Futhermore, in non-alcoholic fatty liver disease (NAFLD) they show evidence of improved liver histology and hepatic steatosis (126) in PCOS they may help in regulation of weight, reproductive and metabolic parameters simultaneously (127) GLP1-Ras are also under study with their ability to modulate the hemodynamic and inflammatory pathways to treat CKD (128) and Heart failure (129)
Furthermore, this effect involves hypothalamic AMPK inhibition as pharmacological and genetic activation of AMPK ablates the effect of liraglutide on BAT thermogenesis
How Semaglutide and Tirzepatide Compare Both semaglutide and tirzepatide are typically administered as once-weekly injections and are used as part of a broader treatment plan that includes lifestyle support and nutritional guidance
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