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Metagenomic biomarker discovery and explanation
L-cysteine supplementation upregulates glutathione (GSH) and vitamin D binding protein (VDBP) in hepatocytes cultured in high glucose and in vivo in liver, and increases blood levels of GSH, VDBP, and 25-hydroxy-vitamin D in Zucker diabetic fatty rats
The main phenotype of loss-of-function mutations in arGSTs is the decreased content of anthocyanins ( 1 ) 19,20,21,22,23,24,25,26,27,28 and proanthocyanidins 27 , which can be well explained by an incomplete biosynthesis due to the absence of an essential enzyme
At a concentration of 5 M, the inhibitory effect of OA-VI12 on melanin production was comparable to that of arbutin, but OA-VI12 showed a significantly stronger inhibitory effect at this concentration
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