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It has been hypothesised, based on preclinical and early human data, that activation of the glucagon receptor in addition to GLP-1 and GIP receptors may promote greater energy expenditure and fat oxidation compared to agents with fewer receptor targets
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10.1016/j.foodchem.2021.130859 254
The peptide appears to act through direct interaction with adipocytes (fat cells), potentially involving activation of hormone-sensitive lipase (HSL) and modulation of -adrenergic receptor signaling pathways
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