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Options for switching include moving from injectable to oral or sublingual semaglutide , transitioning between tirzepatide and semaglutide , or considering a dose conversion to a different GLP-1 agonist at a lower relative dose

A meta-analysis showed that treatment with a tumor necrosis factor-alpha (TNF-alpha) inhibitor, a first-line treatment for UC, was less likely to work well for people with BMIs in the obese range

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The authors show that GIPR activation enhances entry of GLP-1R agonists into the brain, and this process depends on oligodendrocyte GIPR signaling

doi:10.1016/j.bmcl.2019.08.015