PLoS One 3 , e2935 (2008)
Behavioral alterations from MPs exposure demonstrated clear dose-response and particle-specific patterns (Jiang et al., 2023) reported no alteration in neuropsychiatric symptoms at 12 weeks but observed clear effects after 24 weeks of exposure, supporting cumulative neurotoxicity
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S100A8/S100A9-induced increase in NADPH-oxidase activity is via S100A9 transport of the cofactor arachidonic acid to the NADPH oxidase complex, and interaction of S100A8 with cytosolic phox proteins facilitating the enzyme assembly (114)
IV Infusion: A tiny needle is inserted in the arm vein, like a traditional IV method, and the infusion commences