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They also saw a smaller but meaningful increase in PYY (about 70% over control)

Furthermore, compared to dulaglutide, tirzepatide at a dose of 0.75 mg once weekly was more effective at controlling blood glucose levels in this cohort

Even at 0.125 mg kg 1 , AzaA8 blunted the glucose rise relative to saline-treated controls

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In parallel, GLP-1-mediated insulinotropic effects offset hyperglycemia risks traditionally associated with glucagon signaling