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Presented for research literature review only Zawilska J et al
The genes are located on chromosomes 21, 6, and 4, respectively (21q22.1, 6q25.3 and 4p15.3-p15.1)
Conclusion This study demonstrates that atorvastatin (ATO) disrupts hepatic redox homeostasis and antioxidant defenses, leading to mitochondrial dysfunction, activation of apoptotic pathways, and functional impairment of hepatic CYP3A1 activity, with associated hepatic alterations
Glia 65:12051226 Abbott NJ, Romero IA (1996) Transporting therapeutics across the blood-brain barrier
J.CarrollJ
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