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A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis
The unhealthy pancreas does not make enough intrinsic factor, and deficiency ensues when pancreatitis becomes chronic and, B12 deficiency ensues
However, Norethisterone is not suitable for everyone, and critically, it is is generally not recommended alongside hormonal contraception due to increased hormone exposure and associated risks
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known trial-reported adverse effects include gastrointestinal symptoms, injection site reactions, increased heart rate, and hypoglycaemia risk
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