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(Source: Sabatella et al., Obesity , 2026) Why the Gap Is Partly About Adherence, Not Just the Drug The most important context for these numbers is one the lead researchers themselves emphasized: much of the observed gap reflects how GLP-1 therapy is actually used in the real world, not a ceiling on what the medication can achieve
Bottom line, they work, Matias Muchnick, co-founder and CEO of NotCo, explained in a social media post
The average absorption rate of a oral supplement is only 45 % compared with 90% via an IM shot
Energy deficiency impairs resistance training gains in lean mass but not strength: a meta-analysis and meta-regression. Scandinavian Journal of Medicine and Science in Sports
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