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The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time
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After confirming BCCs efficacy in human serum, we then measured BChE activity in serum from healthy controls (HC) and patients with unipolar depression (UD) and bipolar depression (BD-D)
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