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Start your intake Common Side Effects and Their Clinical Context Gastrointestinal symptomsnausea, vomiting, constipation, and diarrheaare the most frequently reported adverse effects in clinical trials
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It is important to understand that these in vitro models express a different hormonal cocktail and respond to different chemical stimuli than intestinal L-cells in vivo ( The more physiologically relevant studies make use of in vivo transgenic mice, ex vivo perfused intestines or, more recently, crypt organoids derived from human, mouse or porcine guts ( In situ immunostaining and FACS studies have demonstrated that the hormonal secretome of GLP-1-secreting-cells is anatomically dependent
Sitagliptin was also associated with Stevens-Johnson syndrome in postmarketing reports
PMC 2756298
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