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For the side effect phenotypes, we defined separate casecontrol phenotypes for each side effect recorded in the survey, contrasting those who self-rated their side effects as moderate or severe (cases) to those who self-rated their side effects as mild or non-existent (controls)

Semaglutide is a selective GLP-1R agonist

The European Medicines Agency recommended an extension to Wegovy's marketing authorization to add an oral semaglutide formulation for weight management, describing it as the first GLP-1 receptor agonist for weight management developed for oral use in the EU

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while excessively high levels of ROS causing lipid, protein and DNA cell damage are known as oxidative stress (Schieber and Chandel, 2014)