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Tirzepatide becomes the preferred choice when patients experience plateaus on semaglutide, seek maximum weight reduction potential, or carry genetic markers favoring dual-pathway activation (particularly elevated GIPR or FTO variants)
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It can, particularly insulin and sulfonylureas (raising low-blood-sugar risk) and oral medications whose absorption is affected by slower digestion
Oral Contraceptives: Hormonal oral birth control methods may face compromised absorption
10.1002/wps.20725 World Psychiatry 139 KhlebnikovV.van der KempW
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