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That choice is worth more than any theory about mornings versus evenings, because the dominant real-world failure mode is not mistimed doses but missed ones

[7] If the symptoms are serious, frequent injections are typically recommended initially

This is in contrast to the absence of the HLA-B*57:01 allele, which has an NPV of 100% for abacavir hypersensitivity (a reaction distinct from SJS/TEN, though illustrative as an example)

Neurochem Int 37:299306, PMID: 10812215 Varga V, Jenei Z, Janky R, Saransaari P, Oja SS (1997) Glutathione is an endogenous ligand of rat brain N -methyl-d-aspartate (NMDA) and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors

Coln-Rodrguez A, Hannon HE, Atchison WD (2016) Effects of methylmercury on spinal cord afferents and efferentsa review