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For moderate to severe withdrawal symptoms, consider increasing the opioid to the previous dosage, especially if gastrointestinal symptoms are present or consider restarting or supplementing with benzodiazepine therapy

This research was supported by National Institute on Alcohol Abuse and Alcoholism grant R21AA026931.

Some symptoms of a vitamin B12 deficiency include: difficulty thinking brain fog fatigue pale skin weight loss dementia numbness and tingling in hands and feet mood changes decreased appetite constipation A lack of animal protein and following a plant-based diet sans appropriate supplementation can lead to a vitamin B12 deficiency

This transition is essential to keep in mind when planning trials that concentrate on geroscience, as it will ultimately impact the selection of biomarkers for monitoring and enhance existing therapeutic strategies, specifically addressing the biological processes of aging at the physiological systems level

Studies like this provide important information regarding how brain chemistry may change in response to disease and to therapeutic intervention, Dr