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A prospective pilot study run in 2004 involved 18 non-diabetic patients with biopsy-proven NASH and tested hepatic histological improvement as the primary outcome after a 48-week course of pioglitazone: the results showed significant improvement in histology regarding all major features of NASH (steatosis, parenchymal inflammation, cellular injury, and Mallory bodies) including fibrosis, despite a significant increase in body weight [59]
Shirouchi, B., Fukuda, A., & Akasaka, T
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In particular, B12 and B9 deficiencies can cause neural tube defects, which can prevent the spinal cord or brain from developing properly
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