resolve with titration.[1][43] Absolute Contraindications : History of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome type 2.[3][44] Relative Contraindications : Pancreatitis, severe GI disease, pregnancy/breastfeeding.[1][45] Monitoring Parameters : HbA1c, lipids, liver enzymes, renal function every 3 months.[4][46] Regulatory Status FDA Classification : Investigational (Phase 3)

They must be at least 18 years of age and meet one of the following clinical criteria: Body mass index (BMI) greater than or equal to 35 when initiating GLP-1 therapy, BMI greater than or equal to 30 when initiating therapy and a diagnosis of one or more of the following: heart failure with preserved ejection fraction, uncontrolled hypertension (defined as systolic blood pressure above 140 mm Hg or diastolic blood pressure above 99 mm Hg, despite concurrent treatment with two antihypertensive medications), or chronic kidney disease stage 3a or above, BMI greater than or equal to 27 when initiating therapy with a diagnosis of one or more of the following: prediabetes (as defined by the American Diabetes Association), previous myocardial infarction, previous stroke, or symptomatic peripheral artery disease
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The safety and effectiveness of medications for off-label uses may not be established by the FDA