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Key features of this combination include: Two complementary mechanisms of glucose reduction Significant HbA1c reduction potential Additional benefits beyond glycaemic control Reduced risk of hypoglycaemia compared to insulin-based regimens (though caution is needed if combined with insulin or sulphonylureas, which may require dose reduction) How GLP-1 Receptor Agonists and SGLT2 Inhibitors Work Together Understanding the distinct pharmacological mechanisms of these two drug classes helps explain why their combination can be effective
Data availability The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request
Fleury, M.-J
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In comparison, only 21.3% and 6.9% of people taking a placebo reached those goals
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