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Cell Metab (2020) 32:92037
Since subcutaneous adipocytes typically display lower densities of GH receptors than visceral adipocytes, they may not respond as well to GH-induced or Frag 176-191-mediated lipolysis, possibly resulting in differential regional adipose mobilization
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This overlap suggests that FOXO4s activation by oxidative stress and inflammation might follow similar mechanisms, pointing to a broader role of FOXO4 in stress and immune response contexts
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