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I feel ultimately we will end up using these drugs to PREVENT weight gain rather than using them later, but again I lack the proof of concept Clinical trials have never proven what you say...the currently available scientific fact is that obesity is a chronic disease that requires chronic treatment...it is best to stop treatment when the goals are achieved and resume it when the weight returns to rise...this will be more economical and safer for the patient
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This short half-life explains the rapid onset of action pharmacokinetic profile observed in preclinical in vivo models
If you are considering berberine alongside a compounded GLP-1 medication like semaglutide injection or tirzepatide, understanding your genetic predispositions in glucose and peptide pathways can support a more personalized conversation with your provider about timing, dosing, and monitoring needs
Ferrer, I
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