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In contrast, iodine imbalance (insufficient or excess) skews T helper (Th)1/Th17 and regulatory T cell (Treg) populations with nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) activation, predisposing to autoimmune thyroiditis, impairing MPO-derived RIS/ROS-mediated host defence at low iodine, and amplifying ROS-driven oxidative stress, inflammation, and tissue injury at excess iodine
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Gastrointestinal disturbances with B12 supplements typically relate to excipients such as sorbitol, mannitol, or lactose rather than the vitamin itself
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