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The accumulation of amyloid-beta (A) plaques and the hyperphosphorylation of tau proteins contribute to mitochondrial abnormalities and exacerbate oxidative damage

while all three treated groups had benefits as assessed by looking at liver fat area and triglycerides, the Sema + -MSTN/-ActA combination (which had the largest decreases in overall body fat composition) also had the largest benefits in terms of these liver measures (Fig

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The accumulation of TP, TC, and TG significantly impacts blood lipids and visceral organs, particularly the liver [17]

As the potential uses of these drugs expand, such as with recent approvals to prevent heart attacks and strokes in adults with cardiovascular disease who are overweight, the high cost and increased demand for these drugs may increase health spending