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The FDA label describes it as a once-weekly GIP and GLP-1 receptor agonist with a formal dose-escalation schedule, contraindications, a boxed warning about thyroid C-cell tumors seen in rats, and multiple warnings and precautions that clinicians must evaluate

Amgen's MariTide Phase 2 showed no weight loss plateau at 52 weeks (Nov 2024): The absence of a weight loss plateau effect which both semaglutide and tirzepatide display would be a clinically meaningful differentiation if confirmed in Phase 3, potentially enabling greater sustained weight loss

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Claritin (loratadine), Zyrtec (cetirizine), and Xyzal (levocetirizine dihydrochloride) are second-generation antihistamines that cross the blood-brain barrier to a much lesser extent and have significantly fewer side effects like drowsiness and impairment

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