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dose reduction of sulfonylureas or insulin is usually necessary when initiating a GLP-1 receptor agonist, as advised in the Summary of Product Characteristics (SmPC) for each agent
Fukushima S, Kurganov E, Hiratsuka D, Miyata S
Some people do well on GLP-1s and need all the help they can get, and increase doses every four weeks like clockwork until they reach the maximum
Linkage of GLP-1 into elastin-like protein (ELP) polymers that form viscous reservoirs at body temperature and methods for enzyme-controlled release of GLP-1 from reservoirs have also been described but have yet to receive clinical evaluation [44]
Improved mitochondrial efficiency has been observed, but prolonged caloric restriction may reduce mitochondrial biogenesis and oxidative capacity, compromising muscle function even if absolute mass loss is modest [35]
